BioProcessing Fittings PharmaLok Clamps

PharmaLok™ Clamps

PharmaLok with Glass-filled Polyester

Nordson MEDICAL Engineers Rise to the Challenge to Support Vaccine Manufacturing

Each day, more than 40 million doses of the COVID-19 vaccine are administered around the world. At this rate, it will take another six months to achieve the vaccination goal of 75% globally. Disruptions in supply chains caused by material shortages and the pandemic economy have threatened this goal to vaccinate six billion people. Our team of engineers at Nordson MEDICAL have risen to this challenge by seeking out alternative resources and materials to overcome these disruptions and support the global vaccination effort.

One such disruption in the supply chain is the scarcity of glass-filled nylon used to manufacture Nordson MEDICAL's PharmaLok™ Clamps. These clamps play an essential role in the production of vaccines because of their strength connecting sub-components together and sterilization properties - but to overcome material shortages and meet demand - it has become imperative to find an alternative. Once a battery of strength and performance tests had been completed, our team of engineers concluded that a glass-filled polyester material met the same material standards of glass-filled nylon. Within a short time, production resumed and over the following two weeks, production of PharmaLok™ Clamps is being ramped up to meet the surging demand.

Nordson MEDICAL continues to be your single-source partner for the design, development and manufacturing of complex medical devices and component technologies. Our promise to enable our customers to save costs, speed time to market, and simplify supply chain management has not waivered despite this global pandemic and we will continue to take a personal responsibility for quality because lives depend on us.

Supporting test documentation and samples of PharmaLok™ Clamps made with glass-filled polyester material are available by contacting Ravi Narayanan or Taylor Qualls, or Nordson MEDICAL customer service at 1-888-404-5837. For online orders, visit the Nordson MEDICAL store.

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State-of-the-Art Design Allowing for Easy Operation

The biopharmaceutical industry has made a strong move towards single-use technology, so Nordson MEDICAL has developed ground-breaking clamp designs that simplify the assembly process by making it effortless to securely attach sanitary fittings to bag ports and filters.

PharmaLok™ clamps are ASME BPE compliant and operate at a maximum pressure of 80 psi. Single-use and easy-open clamp sizes fit .5" (12.7 mm) to .75" (19.0 mm) and 1" (25.4 mm) to 1.5" (31.8 mm). These clamps provide a significant advancement for the industry, as a number of existing solutions either require tools for closure or consist of multiple components, which turns what should be a simple operation into a difficult and awkward process.

"As a founding member of BPSA, Nordson MEDICAL has been fortunate enough to have insight into the needs of the biopharm industry," comments Ken Davis, Global Marketing Manager for Nordson MEDICAL. "User-friendly solutions are increasingly demanded, and single-use systems have developed into an overwhelming market trend. Incorporating these factors into the PharmaLok™ has resulted in an ideal solution for our customers."

Easily operated with one hand, PharmaLok's patented design allows effortless attachment of fittings to bag ports and filters. The user simply rests the fitting in the PharmaLok's regulation-sized slot, lightly grips the surrounding handles, and listens for the sound of clicks to confirm a secure connection.

Design Upgrades for Improved Performance

As the global expert in the design, development and manufacturing of complex medical devices and component technologies, Nordson MEDICAL is committed to the continuous improvement of our products. This commitment to quality has improved the performance of our PharmaLok™ line of easy-open clamps and tube clamps.

These design upgrades include rounded hinges on all easy-open and tube clamps — allowing users to open these clamps to a full 180°, making it easier to insert both conforming and non-conforming fittings. To prevent the clamps from coming apart when completely opened, the hinges have also been enlarged.

As a result, the entire product line of PharmaLok™ easy-open clamps and tube clamps make end-user interaction easier and more consistent.

PharmaLok Design Changes

Features & Benefits

  • Effortlessly, securely attaches sanitary fittings to bag ports and filters
  • Easy, one-handed closure—no tools needed
  • Materials meet USP Class VI & ISO 10993 criteria
  • ASME BPE 018 DT-7-1 compliant & DIN compliant
  • Repeatable use with consistent pressure on the gasket
  • Tamper evident and zip-tie compatible
  • Use with gamma and autoclave sterilization
  • Audible clicks when securely connected
  • 360° compression
  • Connects both plastic & stainless steel fittings
  • SIP/CIP compatible
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PharmaLok™ Clamps Technical Information

Materials
  • Glass-filled nylon
Sterilization
  • Autoclavable up to 273° F (134° C) for a maximum of 30 min
  • Gamma radiation up to 50 kGy
Sizes Fitting
  • .5" (12.7 mm) to .75" (19.0 mm)
  • 1" (25.4 mm) to 1.5" (38.1 mm)
Maximum Pressure
  • 80 psi (5.5 bar)
    • Conforms to ASME BPE-2014 PM-4.2.2
Temperature
  • Normal operating temperature -94° F (-70° C) to 140° F (60° C)
  • Cryogenic freezing to -112° F (-80° C)
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